Core Anti-Inflammatory Nutrients
by
BiotechAusway
28 Jun 2025
1. Glucosamine & Chondroitin Sulfate
Mechanism |
Clinical Effect |
Promotes cartilage repair |
Stimulates chondrocyte proliferation, accelerates proteoglycan synthesis, repairs damaged cartilage |
Inhibits inflammatory factors |
Blocks NF-κB pathway, reduces release of pro-inflammatory cytokines (IL-6, TNF-α), alleviates synovitis |
Enhances joint lubrication |
Promotes synovial fluid secretion, reduces bone friction (0.3-0.5mm joint space widening after 8 weeks of combined use) |
2. Omega-3 Fatty Acids
Key Action |
Mechanism |
Modulates eicosanoid synthesis |
Reduces ω-6-derived pro-inflammatory prostaglandins, decreases joint swelling (recommended ω-6:ω-3 ratio ≤4:1) |
Suppresses immune overactivation |
Inhibits TLR4 receptor activation in synovial macrophages, blocks inflammatory cascade |
3. Vitamin D
Dual Regulatory Mechanism |
Biological Effect |
Immune balance regulation |
Promotes regulatory T-cell generation, inhibits Th17-mediated autoimmune responses |
Bone-joint synergistic protection |
Increases femoral neck bone density (T-score +0.8), reduces fracture risk by 55% |
II. Adjuvant Anti-Inflammatory Nutrients
1. Antioxidant Combo
Vitamin C:
Promotes collagen synthesis, enhances cartilage elasticity (rich in citrus fruits, bell peppers)
Selenium:
Activates glutathione peroxidase, clears free radicals in joints (2 Brazil nuts/day suffice)
Carotenoids:
Reduces oxidative damage (100g/day pumpkin or carrots)
2. Curcumin
Directly inhibits COX-2 enzyme activity, provides 50% analgesia equivalent to ibuprofen (requires black pepper to enhance absorption)
3. Lactoferrin (LF)
Binds bacterial iron ions to inhibit proliferation, reduces infection-induced synovitis risk
III. Synergistic Nutrient Protocols
Inflammatory Condition |
Recommended Combination |
Synergistic Mechanism |
Osteoarthritis |
Glucosamine 1500mg + Chondroitin 600mg + Vit D 2000IU |
Cartilage repair + Synovitis inhibition |
Rheumatoid Arthritis |
Fish oil (EPA/DHA 3g) + Curcumin 500mg |
Dual-pathway inflammation blockade |
Sports Injuries |
Whey protein 20g + Vitamin C 200mg |
Collagen synthesis + Tissue repair |